Combination Technologies

As the field of surface plasmon resonance (SPR) evolves, a range of combination technologies are gaining traction. These so-called ‘hyphenated technologies’ open up new experimental possibilities. Experiments of this type include SPR-mass spectrometry, SPR-electrochemistry, SPR-photochemistry and SPR-fluorescence. To maximize these combination technologies, scientists need to consider method development and what kinds of SPR systems will allow them to adopt new approaches.

With an open architecture design, custom flow cells and fluidic flexibility options, Reichert SPR systems can grow with your research programs. Expert scientists are on hand to help you develop methods that break new ground in the field, giving your science a competitive edge.

SPR-Mass Spectrometry

An emerging and powerful combination, SPR-mass spectrometry allows researchers to quantify and characterize biomolecular interactions and then verify the specific molecules bound. Scientists can identify both the interaction partner and the structure of the complex formed. SPR-MS can be used to analyze complex biological samples with little or no sample preparation.

For more details, see the following publication for an example of SPR-MS with a Reichert SPR system: Nico Dankbar, Erk Gedig and Simone König. "A Surface Plasmon Resonance/Mass Spectrometry Interface for Maximum Sensitivity." Biomacromolecular Mass Spectrometry 2010, 2, 77- 80.


Our Electrochemistry (Echem) flow cell has proven successful in a variety of different study types. Surface plasmon resonance-electrochemistry experiments use a potentiostat to control the potential applied at the sensor chip (working electrode) surface. While the electrochemistry experiment is being run, SPR data is also being generated.

See the following application note for more information on how our instrument has been used for this type of experiment: “Using Combined Electrochemistry and SPR to Monitor the Electropolymerization.”

Along with this recent publication by Reichert customers: Chun L. Yeung; Parvez Iqbal; Marzena Allan; Minhaj Lashkor; Jon A. Preece; Paula M. Mendes. "Tuning Specific Biomolecular Interactions Using Electro-Switchable Oligopeptide Surfaces." Adv. Funct. Mater 2010, Show All »